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Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis |
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| Authors: | Zainab Samaan Daria Gaysina Sarah Cohen-Woods Nick Craddock Lisa Jones Ania Korszun Mike Owen Andrew Mente Peter McGuffin and Anne Farmer |
| Institution: | (1) Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada;(2) Medical Research Council (MRC) Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK;(3) Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK;(4) Division of Neuroscience, University of Birmingham, Birmingham, UK;(5) Barts and The London, Queen Mary’s School of Medicine and Dentistry, London, UK;(6) Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada |
| Abstract: | BackgroundMigraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of MTHFR with migraine has been inconclusive. We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date. |
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