The accumulation of glycinamide ribotide by ade3 and ade8 mutants of Saccharomyces cerevisiae |
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Authors: | R A Woods I E Jackson |
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Affiliation: | Department of Genetics, The University of Sheffield, Sheffield, S10 STN. U.K. |
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Abstract: | The purine intermediate GAR is present in cell free extracts of and mutants of yeast. It is also detectable following acid hydrolysis of extracts of and which accumulate FGAR and FGAM respectively. GAR accumulation is repressed by growing cells in high levels of adenine. Neither nor accumulate GAR and both prevent accumulation of GAR in and and FGAR in . Since is known to be defective in folate metabolism these results indicate that is blocked in the conversion of GAR→FGAR. |
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