Elevated serum and hepatic tyrosine aminotransferase in voles chronically infected with Trypanosoma brucei gambiense. |
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Authors: | H H Stibbs J R Seed |
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Affiliation: | Laboratory of Parasitology, Department of Biology, Tulane University, New Orleans, Louisiana 70118 U.S.A. |
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Abstract: | Chronic infections of voles (Microtus montanus) with Trypanosoma brucei gambiense result in marked elevations in both serum and hepatic tyrosine aminotransferase. Serum enzyme levels correlate poorly with hepatic levels but well with parasitemia. Because the trypanosome itself contains high levels of this same enzyme, it is hypothesized that lysis of extravascular parasites, possibly due to agglutination by variant-specific antibody, releases parasite enzymes into host tissues, resulting in the observed increase in serum enzyme levels. The possible role of increased tyrosine transamination in the behavioral syndrome of trypanosome-infected voles is considered. |
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Keywords: | African sleeping sickness Tyrosine aminotransferase (EC 2.6.1.5) EC 2.6.1.5 (tyrosine aminotransferase) Voles Enzymes Metabolism |
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