Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid |
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Authors: | Prentice M B James K D Parkhill J Baker S G Stevens K Simmonds M N Mungall K L Churcher C Oyston P C Titball R W Wren B W Wain J Pickard D Hien T T Farrar J J Dougan G |
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Affiliation: | Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London, United Kingdom. m.b.prentice@mds.qmw.ac.uk |
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Abstract: | Population genetic studies suggest that Yersinia pestis, the cause of plague, is a clonal pathogen that has recently emerged from Yersinia pseudotuberculosis. Plasmid acquisition is likely to have been a key element in this evolutionary leap from an enteric to a flea-transmitted systemic pathogen. However, the origin of Y. pestis-specific plasmids remains obscure. We demonstrate specific plasmid rearrangements in different Y. pestis strains which distinguish Y. pestis bv. Orientalis strains from other biovars. We also present evidence for plasmid-associated DNA exchange between Y. pestis and the exclusively human pathogen Salmonella enterica serovar Typhi. |
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