SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension |
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| Authors: | Stanislav Keranov Oliver Dörr Leili Jafari Christoph Liebetrau Till Keller Christian Troidl |
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| Affiliation: | 1. Department of Cardiology and Angiology, University of Giessen, Giessen, Germany;2. DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, Bad Nauheim, Germany;3. stanislav.keranov@innere.med.uni-giessen.de;5. DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, Bad Nauheim, Germany;6. Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany |
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| Abstract: | AbstractAim: This study assessed the utility of SPARC-like protein 1 (SPARCL1) as a biomarker of maladaptive right ventricular (RV) function in patients with pulmonary hypertension (PH).Methods: In this prospective study, we examined SPARCL1 levels in 105 patients with adaptive (n?=?34) and maladaptive RV (n?=?32) pressure overload caused by PH, dilated cardiomyopathy (DCM, n?=?18) with LVEF < 35% and preserved RV function and controls without LV or RV abnormalities (n?=?21).Results: The median SPARCL1 concentration in patients with maladaptive RV function was higher than in those with adaptive RV function (p?p?p?p?p?Conclusion: SPARCL1 shows potential as novel biomarker of RV pathological remodelling and is associated with RV maladaptation and ventriculoarterial uncoupling in PH. |
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| Keywords: | SPARCL1 cardiac remodelling TAPSE/PASP ventriculoarterial uncoupling pulmonary hypertension adaptive and maladaptive right ventricular pressure overload |
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