Diagnostic value of GLUT-1 in distinguishing malignant mesothelioma from reactive mesothelial cells: a meta-analysis |
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Authors: | Shan-Chuan Zhong Xu-Jun Ao Shang-Hai Yu |
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Institution: | 1. Department of Pathology and Clinical Laboratory, 96601 Army Hospital of People’s Liberation Army, Huangshan, China;2. zhongshanchuan@163.com;4. Department of Medical Oncology, 96601 Army Hospital of People’s Liberation Army, Huangshan, China |
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Abstract: | AbstractBackground: Previous studies have demonstrated the diagnostic value of glucose transporter 1 (GLUT-1) to distinguish malignant mesothelioma (MM) from reactive mesothelial cells (RMC), but the results are inconsistent. The purpose of this meta-analysis is to investigate the diagnostic accuracy of GLUT-1 in distinguishing MM from RMC.Methods: A systematical search was conducted until May 2019 in PubMed, Medline, Embase and the Cochrane Library. The revised tool for the quality assessment of diagnostic accuracy studies (QUADAS-2) was used to assess the quality of the eligible studies. The Stata15 and Review Manager5.3 software programmes were used to perform the meta-analysis.Results: A total of 24 studies, including 969?MM patients and 1080 RMC individuals were explored in the meta-analysis. The summary assessments revealed that the pooled sensitivity was 0.73 (95% CI, 0.62–0.81) and the pooled specificity was 0.95 (95% CI, 0.91–0.98). The area under the summary ROC curve (AUC) was 0.93 (95% CI: 0.91–0.95).Conclusions: GLUT-1 is highly accurate to distinguish MM from RMC. |
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Keywords: | Glucose transporter 1 malignant mesothelioma reactive mesothelial cells diagnostic value meta-analysis |
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