GRM7 polymorphisms are not associated with ischemic stroke in Iranian population |
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| Authors: | Mohammad Reza Safari Amirreza Dowlati Beirami Mojtaba Khazaie Alireza Komaki Rezvan Noroozi |
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| Institution: | 1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran;2. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran;4. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | AbstractObjectives: Ischemic stroke is the main neurological cause of acquired incapability in adults and a prominent cause of mortality. Several association studies have been conducted to explore the role of candidate genes in this neurological condition.Methods: In the present study, we aimed at identification of association between Glutamate Metabotropic Receptor 7 (GRM7) and risk of ischemic stroke in Iranian population. Two intronic variants within this gene (rs6782011 and rs779867) were genotyped in 318 sporadic ischemic stroke cases and 300 unrelated, healthy controls individuals.Results: No significant difference was found in allele, genotype or haplotype frequencies of these SNPs between cases and controls after correction for multiple comparisons.Conclusion: Consequently, the assessed GRM7 variants are not implicated in risk of ischemic stroke in Iranian population. |
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| Keywords: | GRM7 ischemic stroke polymorphism |
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