Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells <Emphasis Type="Italic">in vitro</Emphasis> and <Emphasis Type="Italic">in ovo</Emphasis> by free and nanoparticle-encapsulated redox dye,DCPIP |
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| Authors: | Fadee G Mondalek Sivapriya Ponnurangam Janita Govind Courtney Houchen Shrikant Anant Panayotis Pantazis Rama P Ramanujam |
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| Institution: | (1) Swaasth, Inc, 800 Research Parkway Suite 350, 73104 Oklahoma City, OK, USA;(2) College of Medicine, University of Oklahoma Health Sciences Center, 73104 Oklahoma City, OK, USA;(3) Department of Cell Biology, University of Oklahoma Health Sciences Center, 73126 Oklahoma City, OK, USA;(4) ADNA, Inc, Research Parkway Suite 350, 73104 Oklahoma City, OK, USA |
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| Abstract: | Background The redox dye, DCPIP, has recently shown to exhibit anti-melanoma activity in vitro and in vivo. On the other hand, there is increasing evidence that synthetic nanoparticles can serve as highly efficient carriers of drugs
and vaccines for treatment of various diseases. These nanoparticles have shown to serve as potent tools that can increase
the bioavailability of the drug/vaccine by facilitating absorption or conferring sustained and improved release. Here, we
describe results on the effects of free- and nanoparticle-enclosed DCPIP as anti-angiogenesis and anti-inflammation agents
in a human colon cancer HCT116 cell line in vitro, and in induced angiogenesis in ovo. |
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