| Vax基因与视觉神经系统的早期发育 |
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| 引用本文： | 刘阳,赫荣乔.Vax基因与视觉神经系统的早期发育[J].生物化学与生物物理进展,2000,27(4):345-347. |
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| 作者姓名： | 刘阳 赫荣乔 |
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| 作者单位： | 中国科学院生物物理研究所,视觉信息加工开放实验室,北京,100101 |
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| 摘 要： | 视觉神经系统的发育与形成是一个相当复杂的过程，其基因调控机理是神经发育生物学领域的研究热点.Vax基因家族是新近发现的一类与视觉神经系统发育密切相关的同源异型盒基因，调控前脑、眼原基、视泡、视柄以及视网膜的发育.Vax-1参与色素上皮和视柄的分化；Vax-2则在视网膜及视神经背腹轴建立方面起重要作用.Vax基因的研究将对阐明视觉神经系统发育调控机制提供新的认识.
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| 关 键 词： | 视觉神经系统，Vax，同源异型盒基因，发育，Pax |
| 收稿时间： | 2000/3/20 0:00:00 |
| 修稿时间： | : |
Early Morphogenesis of Visual System Is Related to Vax Family |
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| LIU Yang and HE Rong-Qiao.Early Morphogenesis of Visual System Is Related to Vax Family[J].Progress In Biochemistry and Biophysics,2000,27(4):345-347. |
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| Authors: | LIU Yang and HE Rong-Qiao |
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| Institution: | Laboratory of Visual Information Processing, Institute of Biophysics, The Chinese Academy of Sciences,Beijing 100101, China;Laboratory of Visual Information Processing, Institute of Biophysics, The Chinese Academy of Sciences,Beijing 100101, China |
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| Abstract: | Development and morphogenesis of visual system is a complicated procedure, and the gene regulation is widely paid attentions by neurodevelopmental biologists. Vax (ventral anterior homeobox) family was found in 1998, which is related to development of forebrain, optic vesicle, eye-predium, optic stalk and neuroretina. Vax-1 is involved in differentiation of pigmented epithelium and optic stalk, while Vax-2 could function in the establishment of the dorso-ventral axis of the retina and visual system. Investigation of Vax genes will be helpful to understand the mechanism of molecular events, which happened during the early development of the visual system. |
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| Keywords: | visual system ventral anterior homeo-box (Vax) homeobox development paired box-containing gene (Pax) |
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