An indomethacin sensitive suppressor factor released by macrophages of leprosy patients |
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Authors: | T J Birdi P R Salgame P R Mahadevan N H Antia |
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Institution: | (1) The Foundation for Medical Research, 84-A, R. G. Thadani Marg, Worli, 400 018 Bombay, India |
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Abstract: | Reduction inF
c receptor expression as assayed by ‘erythrocyte’ rosetting of macrophage cultures from long term treated lepromatous leprosy
patients (bactereologically negative) was seen in the presence of viableMycobacterium leprae. Macrophages with and without intracellular bacilli demonstrated this reduction. On the basis of this observation the conditioned
medium ofMycobacterium leprae infected macrophage cultures of lepromatous patients, were tested on macrophages from normal individuals for 3H]-leucine incorporation and antigen specific physical interaction with lymphocytes. Both these parameters showed decreased
values as compared to the controls which were not exposed to this conditioned medium. Lymphocyte transformation toMycobacterium leprae in leucocyte cultures of normal individuals was also reduced in the presence of the conditioned medium from lepromatous patients’
macrophages. The indication that this factor may be a prostaglandin was suggested by the observation that its synthesis was
inhibited by indomethacin. Its importance in the non-specific depression in cell-mediated immunity seen in lepromatous patients
is discussed. |
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Keywords: | Macrophage lepromatous leprosy prostaglandins |
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