Direct cadherin-activated cell signaling: a view from the plasma membrane |
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| Authors: | Yap Alpha S Kovacs Eva M |
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| Affiliation: | School for Biomedical Science and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia 4072. a.yap@mailbox.uq.edu.au |
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| Abstract: | Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane. |
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| Keywords: | cadherin Rac actin cytoskeleton Rho GTPase PI3 kinase |
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