Phosphorylation and functional modification of calmodulin-dependent protein kinase IV by cAMP-dependent protein kinase |
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Authors: | I Kameshita H Fujisawa |
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Institution: | Department of Biochemistry, Asahikawa Medical College, Japan. |
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Abstract: | Calmodulin-dependent protein kinase IV (CaM-kinase IV), a neuronal calmodulin-dependent multifunctional protein kinase, undergoes autophosphorylation in response to Ca2+ and calmodulin, resulting in activation of the enzyme (Frangakis et al. (1991) J. Biol. Chem. 266, 11309-11316). In contrast, the enzyme was phosphorylated by cAMP-dependent protein kinase, leading to a decrease in the enzyme activity. Thus, the results suggest differential regulation of CaM-kinase IV by two representative second messengers, Ca2+ and cAMP. |
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