Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid |
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| Authors: | Marian S Kafka and Charles Y C Pak |
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| Institution: | From the Endocrinology Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014 |
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| Abstract: | Insulin in low concentrations inhibits the uptake of Ca++ by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca++ adsorbed to the monolayer. These effects of insulin are more pronounced at higher insulin concentrations. Evidence is presented that a relatively intact insulin molecule competes with Ca++ for the free phosphate group of the monolayer. Albumin has a slight inhibitory action on calcium uptake and parathyroid hormone has no observable action on calcium uptake or release. |
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