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Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage |
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| Authors: | Shuhei Otsuki Noboru Taniguchi Shawn P Grogan Darryl D'Lima Mitsuo Kinoshita Martin Lotz |
| Institution: | (1) Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA;(2) Department of Orthopedic Surgery, Osaka Medical College, 2–7 Daigaku-machi Takatsuki, 569-8686 Osaka, Japan |
| Abstract: | IntroductionChanges in sulfation of cartilage glycosaminoglycans as mediated by sulfatases can regulate growth factor signaling. The aim of this study was to analyze expression patterns of recently identified extracellular sulfatases Sulf-1 and Sulf-2 in articular cartilage and chondrocytes. |
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