(1) Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA;(2) Department of Orthopedic Surgery, Osaka Medical College, 2–7 Daigaku-machi Takatsuki, 569-8686 Osaka, Japan
Abstract:
Introduction
Changes in sulfation of cartilage glycosaminoglycans as mediated by sulfatases can regulate growth factor signaling. The aim of this study was to analyze expression patterns of recently identified extracellular sulfatases Sulf-1 and Sulf-2 in articular cartilage and chondrocytes.