Chemical synthesis of cellulose and cello-oligomers using a hydrolysis enzyme as a catalyst |
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Authors: | Shiro Kobayashi Shin-ichiro Shoda |
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Affiliation: | Department of Molecular Chemistry and Engineering, Faculty of Engineering, Tohoku University, Sendai 980, Japan |
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Abstract: | Regio- and stereo-selective synthesis of polysaccharides and oligosaccharides has been achieved by using glycosyl fluorides as substrates for cellulases. This methodology has successfully been applied to the first synthesis of cellulose via a non-biosynthetic pathway as well as to a selective preparation of cello-oligosaccharides and unnatural oligosaccharides. Using the enzymatic polymerization, it is possible to control the relative direction (parallel or anti-parallel) of each glucan chain in the synthetic cellulose in vitro. Based on these results, a new concept of ‘allos-selectivity’ in polymer synthesis has been proposed. |
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Keywords: | enzymatic polymerization cellulose I cellulase |
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