The isoprostanes: Unique bioactive products of lipid peroxidation |
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| Authors: | Tsan-Zon Liu Dr Arnold Stern Jason D Morrow |
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| Institution: | (1) Department of Medical Research, Yuan's General Hospital, Kaohsiung, Taiwan, ROC;(2) Department of Pharmacology, NYU Medical Center, 550 First Avenue, 10016 New York, NY, USA;(3) Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn., USA |
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| Abstract: | The development of a specific, reliable and noninvasive method for measuring oxidative stress in humans is essential for establishing the role of free radicals in human diseases. Currently, accurate techniques to assess oxidant injury in vivo are extremely limited although a number of approaches are being investigated. Of these, the measurement of specific products of nonenzymatic lipid peroxidation, the F2-isoprostanes (F2-IsoPs), appears to be a more accurate marker of oxidative stress in vivo in humans than other available methods. The purpose of this brief review is to acquaint the reader with the IsoPs from a biochemical perspective and to provide information regarding the utility of quantifying these compounds as indicators of oxidant stress. |
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| Keywords: | Isoprostanes Oxidative stress Lipid peroxidation Gas chromatography Mass spectrometry Human disease |
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