Blood rheology in acute mountain sickness and high-altitude pulmonary edema. |
| |
Authors: | W H Reinhart B Kayser A Singh U Waber O Oelz P B?rtsch |
| |
Affiliation: | Department of Internal Medicine, University of Bern, Switzerland. |
| |
Abstract: | The role of blood rheology in the pathogenesis of acute mountain sickness and high-altitude pulmonary edema was investigated. Twenty-three volunteers, 12 with a history of high-altitude pulmonary edema, were studied at low altitude (490 m) and at 2 h and 18 h after arrival at 4,559 m. Eight subjects remained healthy, seven developed acute mountain sickness, and eight developed high-altitude pulmonary edema. Hematocrit, whole blood viscosity, plasma viscosity, erythrocyte aggregation, and erythrocyte deformability (filtration) were measured. Plasma viscosity and erythrocyte deformability remained unaffected. The hematocrit level was lower 2 h after the arrival at high altitude and higher after 18 h compared with low altitude. The whole blood viscosity changed accordingly. The erythrocyte aggregation was about doubled 18 h after the arrival compared with low-altitude values, which reflects the acute phase reaction. There were, however, no significant differences in any rheological parameters between healthy individuals and subjects with acute mountain sickness or high-altitude pulmonary edema, either before or during the illness. We conclude that rheological abnormalities can be excluded as an initiating event in the development of acute mountain sickness and high-altitude pulmonary edema. |
| |
Keywords: | |
|
| 点击此处可从《Journal of applied physiology》浏览原始摘要信息 |
|
点击此处可从《Journal of applied physiology》下载全文 |
|