Desmin-containing intermediate filaments: structural analysis using monoclonal antibodies |
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Authors: | M J Allen P Johnson |
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Affiliation: | Department of Chemistry, Ohio University, Athens 45701. |
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Abstract: | 1. Monoclonal antibodies have been raised against N- and C-terminal desmin sequence regions. 2. The antibodies decorated desmin intermediate filaments in a helical fashion with four antibody molecules per helix turn. 3. The filaments could be decorated with both types of antibody consecutively. 4. These results support a model of intermediate filament assembly in which the tetrameric protofilaments are aligned in a staggered fashion with partial overlapping of the central rod domain regions of the desmin sequence. |
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