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Intraflagellar transport and cilia-dependent diseases |
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| Authors: | Pazour Gregory J Rosenbaum Joel L |
| Institution: | a Dept Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA b Dept Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA |
| Abstract: | Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required for the assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates. |
| Keywords: | cilia flagella intraflagellar transport IFT kinesin dynein polycystic kidney disease polycystin-2 situs inversus retinitis pigmentosa retinal degeneration |
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