Mesenchymal stem cells from osteoporotic patients reveal reduced migration and invasion upon stimulation with BMP-2 or BMP-7 |
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| Authors: | Florian Haasters,Denitsa Docheva,Christoph Gassner,Cvetan Popov,Wolfgang Bö cker,Wolf Mutschler,Matthias Schieker,Wolf Christian Prall |
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| Affiliation: | Experimental Surgery and Regenerative Medicine, Department of Hand-, Plastic- and Trauma Surgery, Ludwig-Maximilians-University (LMU), Nussbaumstr. 20, D-80336 Munich, Germany |
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| Abstract: | Fractures to the osteoporotic bone feature a delay in callus formation and reduced enchondral ossification. Human mesenchymal stem cells (hMSC), the cellular source of fracture healing, are recruited to the fracture site by cytokines, such as BMP-2 and BMP-7. Aim of the study was to scrutinize hMSC for osteoporosis associated alterations in BMP mediated migration and invasion as well as in extracellular matrix (ECM) binding integrin expression. |
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| Keywords: | Mesenchymal stem cells (MSC) Migration Invasion Integrin expression |
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