Effect of mitochondrial tRNA mutation on the clinical and biochemical characteristics of Chinese essential hypertensive subjects |
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Authors: | Yan Lu Tiehui Xiao Feng Zhang Yanming Chen Yuqi Liu Yang Li Yun dai Chen Zongbin Li Minxin Guan |
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Institution: | 1. Department of Geriatric Comprehensive Surgery, Chinese PLA General Hospital, Beijing 100853, China;2. Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China;3. Department of Emergency, Lingqiu People’s Hospital of Datong City, Shanxi 034400, China;4. Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China;5. Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China;6. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;g Department of Genetics, College of Life Sciences, Zhejiang University, Zhejiang, China |
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Abstract: | Mitochondrial dysfunction has been potentially implicated in both human and experimental hypertension. We performed the mutational analysis of tRNALys gene by PCR amplification and subsequent sequence analysis of the PCR fragments from 990 Chinese essential hypertensive subjects. We also made a comparative analysis of the collected data of the essential hypertension subjects who carried tRNALys mutation and those who did not carry the mutation using the methods of 1:1 case-control study. We totally found 7 mutation sites in 10 subjects. The onset ages of the individuals carrying the mutation were earlier than those who did not bear them. The level of blood urea nitrogen in hypertension subjects who carried tRNALys mutation was higher than the hypertension subjects who did not carried tRNALys mutation, while the serum potassium was significantly lower. The level of platelet count in hypertension subjects who carried tRNALys mutation was lower. The level of ventricular septal thickness in hypertension subjects who carried tRNALys mutation was higher and the level of left ventricular end diastolic diameter in hypertension subjects was significantly lower. Mitochondrial tRNALys mutations might result in the change of their structure and function, and then damaged the blood metabolism, the balance of the blood electrolyte, the steady-state of the blood cells and the heart structure and function, which were involved in the progress of the essential hypertension. Part of the essential hypertension patients clinically presented the characters of maternal inheritance, which might be associated with the tRNALys mutation. |
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Keywords: | Mitochondrial tRNALys Gene mutation Essential hypertension Clinical and biochemical characteristics |
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