Neolignans from the seeds of Prunus tomentosa (Rosaceae) and their chemotaxonomic interest |
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| Affiliation: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, PR China;3. Anhui Institute for Food and Drug Control, Hefei 230051, PR China;1. Shandong Academy of Tranditional Chinese Medicine, #7 Yanzi Shanxi Road, Jinan, 250014, Shandong Province, PR China;2. Binzhou Chinese Medicine Hospital, #539 Bohai Eight Road, Bincheng District, Binzhou, 252600, Shandong Province, PR China;3. Shandong Provincial Qianfoshan Hospital, Shandong University, # 16766 Jingshi Road, Jinan, 250014, Shandong Province, PR China;4. People''s Hospital of Chengyang, # 600 Changcheng Road, Chengyang District, Qingdao, 266109, Shandong Province, PR China;5. Affiliated Hospital of Shandong University of TCM, # 16369 Jingshi Road, Jinan, 250014, Shandong Province, PR China;6. Zaozhuang Hospital of Traditional Chinese Medicine, # 2666, Taihang Mountain Road, Xuecheng District, Zaozhuang, 277000, PR China;1. Chemistry & Bioprospecting Division, Institute of Wood Science and Technology, Malleshwaram 18th Cross, Bengaluru, 560003, India;2. Chemistry & Bioprospecting Division, Forest Research Institute, Dehradun, 248006, India;3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991, Moscow, Russian Federation;1. College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China;2. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China;3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China;1. Jinqiu Hospital of Liaoning Province, Shenyang, 110015, PR China;2. Liaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, 110866, PR China;1. State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reduction Pharmaceutical Equipment, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;3. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China;4. College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China |
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| Abstract: | The role of neolignans in the chemotaxonomy of the genus Prunus has long been neglected. In this study, two new dihydrobenzofuran neolignans tomentosanans A (12) and B (14), together with 15 known neolignans, were isolated from the seeds of Prunus tomentosa. This is the first report on the occurrence of compounds 1–12, 14, 15 and 17 in the genus Prunus. The biosynthetic pathways of these neolignans are also summarized. Together, these neolignans represent a phytochemical fingerprint for P. tomentosa, which may be used for identification of Prunus species. |
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| Keywords: | Rosaceae Neolignans Tomentosanans Biosynthetic pathway Chemotaxonomy |
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