Phenolic constituents from the roots of Rosa laevigata (Rosaceae) |
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| Institution: | 1. Department of Biochemistry & Molecular Medicine, University of California Davis, Davis CA 95616, USA;2. Physical and Life Science Directorate, Lawrence Livermore National Laboratory, Livermore CA 94550, USA;3. M.I.N.D. Institute and Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento CA 95817, USA;4. Institute of Organic and Medicinal Chemistry, University of Pécs, H-7624 Pécs, Szigeti st. 12. Pécs, Hungary;1. College of Pharmacology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;2. Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China;3. The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Chengdu 611137, China;4. Department of Pharmacology, Chengdu Medicine College, Chengdu 610065, China;1. CAS Key Laboratory of Crust-Mantle Materials and Environments, School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China;2. CAS Key Laboratory of Earth''s Deep Interior, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China |
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| Abstract: | Chemical investigation of the root of Rosa laevigata led to the isolation of sixteen phenolic compounds, including seven flavonoids (1–7), five condensed tannins (8–12), two stilbenes (13 and 14) and two benzoic acid derivatives (15 and 16). Their structures were identified as (+)-catechin (1), (+)-gallocatechin (2), (2R, 3S, 4S)-cis- leucocyanidin (3), (2R, 3S, 4S)-cis-leucofisetinidin (4), (2S, 3R, 4R)-cis- leucofisetinidin (5), dehydrodicatechin A (6), phloridzin (7), procyanidin B3 (8), fisetinidol-(4α, 8)-catechin (9), guibourtinidol- (4α, 8)-catechin (10), ent- isetinidol -(4α, 6)-catechin (11), fisetinidol-(4β, 8)-catechin (12), (Z)-3-methoxy-5-hydroxy- stilbene (13), (Z)-piceid (14), gallic acid (15) and 4-hydroxybenzoic acid- 4-O-β-D-glucopyranoside (16). Among them, compounds 3–7, 9–14, and 16 were isolated from R. laevigata for the first time, and compounds 3–7, 9, 10, 12–14 and 16 were reported for the first time from the genus Rosa. The chemotaxonomic significance of these compounds was summarized. |
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| Keywords: | Rosaceae Phenolic constituents Chemotaxonomy |
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