The properties of membranes formed from cyclopentanoid analogues of phosphatidylcholine |
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Authors: | Michael A Singer Mahendra K Jain Henry Z Sable Henry J Pownall William W Mantulin Mark D Lister Anthony J Hancock |
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Institution: | 1. Department of Medicine, Queen''s University, Kingston, Ontario K7L 3N6 Canada;2. Department of Chemistry, University of Delaware, Newark, DE 19711, U.S.A.;3. Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, U.S.A.;4. Department of Medicine, Baylor College of Medicine, Houston, TX 77030, U.S.A.;5. Department of Chemistry, University of Missouri, Kansas City, MO 64110 U.S.A. |
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Abstract: | We have examined the thermal characteristics and barrier properties of vesicles formed from six analogues of (DPPC). These analogues differ from DPPC in that the glycerol backbone has been replaced by each of the diastereoisomeric cyclopentane-1,2,3-triols. All of these compounds have main gel to liquid-crystal phase transition temperatures within 5 Kelvin of DPPC and four possess comparable enthalpies and entropies of transition. For two of the analogous, however, the values of the enthalpy and entropy of transition are more than double that of DPPC. The permeability characteristics and organization (as measured by diphenylhexatriene fluorescence depolarization) of vesicles formed from these two compounds suggest that their large transition enthalpy and entropy result from either a reorganization of the polar head group region during the transition or interdigitation of the acyl chains of opposing monolayers. |
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Keywords: | Model membrane Phosphatidylcholine analog Cyclopentanetriol Phase transition Fluorescence depolarization Differential scanning calorimetry |
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