Exchange of phosphatidylcholine between small unilamellar liposomes and human plasma high-density lipoprotein involves exclusively the phospholipid in the outer monolayer of the liposomal membrane期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Exchange of phosphatidylcholine between small unilamellar liposomes and human plasma high-density lipoprotein involves exclusively the phospholipid in the outer monolayer of the liposomal membrane

Authors:	Gerrit Scherphof Babs Van Leeuwen Jan Wilschut Jan Damen

Affiliation:	Laboratory of Physiological Chemistry, State University, Bloemsingel 10, 9712 KZ Groningen The Netherlands

Abstract:	By making use of the capacity of phospholipase A₂ to degrade selectively the phospholipid in the outer half of the lipid bilayer of small unilamellar phospholipid/cholesterol vesicles without affecting the retention of a vesicle-encapsulated solute, we demonstrated that the exchange of phosphatidylcholine between such vesicles and human high density lipoprotein involves exclusively the phosphatidylcholine present in the outer monolayer of the vesicle membrane.

Keywords:	Lipoprotein HDL Liposome Phospholipase Membrane asymmetry Phospholipid exchange HDL high-density lipoproteins
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