A new semi-automated instrument to improve the fine needle aspiration procedure during breast lesion cell sampling |
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| Authors: | H Wiksell V Ekstrand C Wadström G Auer |
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| Institution: | 1. Addictions Program and Neurogenetics Laboratory, Centre for Addiction and Mental Health, 33 Russell St., R3020, Toronto, ON M5S 2S1, Canada;2. Department of Psychiatry, University of Toronto, 250 College St., R129, Toronto, ON M5T 1R8, Canada;3. Clinical Research Department, Centre for Addiction and Mental Health, 250 College St., R 648, Toronto, ON M5T 1R8, Canada;4. Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Rm. 509, New York, NY 10032, USA;5. Gambling Outpatient Unit, Department of Psychiatry, University of São Paulo, Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP 05403-903, Brazil;6. Department of Psychiatry, University of São Paulo Medical School, Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP 05403-903, Brazil;7. Neurogenetics Laboratory, Centre for Addiction and Mental Health, Toronto, Canada;8. Departments of Psychology and Psychiatry, University of Toronto, Canada;9. Research Program, Centre for Addiction and Mental Health, 1265 Military Trail, Toronto, ON M1C 1A4, Canada;1. Department of Neurology, Emory University School of Medicine, USA;2. Georgia Institute of Technology, School of Psychology, USA;1. Department of Cardiology, Aarhus University Hospital, Denmark;2. Department of Medicine, Regional Hospital Randers, Denmark;3. Department of Medicine, Regional Hospital Herning, Denmark;4. Department of Cardiology, Regional Hospital Horsens, Denmark |
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| Abstract: | A large and increasing number of women in the western world will at some point during their life be investigated morphologically for some type of breast lesion. Fine Needle Aspiration (FNA) is one morphological method which is considered to be the fastest, cheapest and the most patient-friendly approach. However, the frequency of conclusive samples using this method varies and is often too low, especially when performed by unexperienced operators. In this study we have developed and tested a new semi-automated instrument (“CytoTest”) designed for FNA which is intended to improve the efficacy of the technique by increasing the percentage of conclusive samples. A total of 443 consecutive aspiration procedures on palpable breast lesions were performed to compare this new “CytoTest” equipment with the standard protocol using the same type of needles. We conclude that by increasing the extent and frequency of the reciprocatory motions used by an experienced sampling operator as well as enhancing the ejection pressure, the cellular yield can be increased almost three folded compared to the standard protocol. For cases with high amounts of non-diagnostic material (such as blood or cystic fluid) which were discarded, up to four times more sample could be obtained. Furthermore, the frequency of sparse samples under 1 mg was halved with use of the “CytoTest”. |
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