Decreased ketonaemia in the monosodium glutamate-induced obese rats |
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| Authors: | T Nakai T Tamai H Takai S Hayashi R Fujiwara S Miyabo |
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| Affiliation: | 1. Department of Physiology, Faculty of Basic Medical Science, University of Ibadan, Ibadan, Oyo, Nigeria;2. Department of Physiology, School of Health and Health Technology, Federal University of Technology, Akure, Ondo, Nigeria;1. Department of Medicine and Division of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA;2. Department of Cardiac Surgery, Ludwig Maximilians University Munich, Munich, Germany;3. Fraunhofer Institute for Cell Therapy and Immunology, University of Leipzig, Leipzig, Germany;4. Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany;1. Institution of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada;2. Orthopaedics Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, Canada;3. Department of Physics and Institute for Optical Sciences, University of Toronto, Toronto, ON, Canada;4. Department of Chemical & Physical Sciences, University of Toronto Mississauga, Mississauga, ON, Canada;5. Department of Surgery, University of Toronto, Toronto, ON, Canada;6. Techna, University Health Network, Toronto, ON, Canada;1. Departamento de Genética y Biología Molecular, Cinvestav Unidad Zacatenco, Av IPN 2508, Ciudad de México 07360, Mexico;2. Departamento de Farmacología, Cinvestav Unidad Zacatenco, Av IPN 2508, Ciudad de México 07360, Mexico;3. Departamento de Nutrición y Bioprogramación, INPer, Ciudad de México, Mexico;4. Departamento de Biología Celular, Facultad de Ciencias, UNAM, Ciudad de México, Mexico |
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| Abstract: | Plasma concentrations of total ketone bodies, acetoacetate (AcAc) and 3-hydroxybutyrate (3-OHBA) in monosodium glutamate (MSG)-induced obese rats were measured. MSG-treated rats showed higher Lee's indices, shorter naso-anal and tail length, and a more marked intraperitoneal fat deposition than control rats. Plasma concentrations of glucose, free fatty acid, triglyceride and phospholipids were significantly increased in the MSG-treated rats as compared to the control rats (24 weeks-old). Plasma levels of total ketone bodies, AcAc and 3-OHBA were all decreased in the MSG-treated rats as compared to control rats. The ratio, 3-OHBA/AcAc in the MSG-treated rats were not different from those in the control rats. |
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