Effects of the Convulsant Methionine Sulfoximine on Striatal Dopamine Metabolism |
| |
| Authors: | Jeffrey D Rothstein Boris Tabakoff |
| |
| Institution: | Department of Physiology and Biophysics, University of Illinois, and Alcohol and Drug Abuse Research and Training Program, University of Illinois at the Medical Center;Westside Veterans Administration Medical Center, Chicago, Illinois, U.S.A. |
| |
| Abstract: | Experiments were conducted to investigate the effects of the convulsant L-methionine-DL-sulfoximine (MSO) on striatal dopamine (DA) metabolism. Intraventricular injections of MSO produced a transient increase in striatal DA release followed by inhibition of DA release for up to 3 days, which paralleled the inhibition by MSO of the enzyme glutamine synthetase (GS). DA synthesis was decreased for up to 24 h after injection of MSO, but returned to normal within 3 days after MSO administration. Intrastriatal injections of MSO produced a pronounced decrease in striatal DA release and inhibition of striatal GS activity 24 h postinjection but, unlike intraventricular MSO, did not produce behavioral convulsions. Glutamate-DA interactions may be responsible for the observed effects. |
| |
| Keywords: | Convulsants Dopamine Glial cells Glutamate Glutamine synthetase Methionine sulfoximine |
|
|
