Influences of Nano-TiO2 on the chloroplast aging of spinach under light |
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Authors: | Fashui Hong Fan Yang Chao Liu Qing Gao Zhigang Wan Fugen Gu Cheng Wu Zhenni Ma Juan Zhou Ping Yang |
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Institution: | (1) Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, 34850 Istanbul, Turkey;(2) Department of Chemistry, Arts and Science Faculty, Yildiz Technical University, Davutpasa, 34210 Istanbul, Turkey |
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Abstract: | The aim of this study was to investigate the biochemical effects of niacin and chromium(III)-chloride on serum lipid peroxidation,
uric and sialic acids, and the extent of lipid peroxidation and glutathione levels in skin and lung tissues of hyperlipidemic
rats.
In this study, female Swiss albino rats, 12 mo old, were used. They were randomly divided into four groups. Group I animals
were fed with a standard pellet diet and water ad libitium. Group II rats were fed with a standard pellet diet and were treated with a dose of 250 μg/kg body weight CrCI3·6H2O and 100 mg/kg body weight niacin, for 45 d, by the gavage technique. Group III rats were fed a lipogenic diet in which 2%
cholesterol, 0.5% cholic acid, and 20% sunflower oil were added to the pellet chow. In addition, the animals in this group
drank water containing 3% ethanol. This regime was maintained for 60 d. The rats in group IV were maintained in the same food
and drink regime as the animals in group III. After 2 wk, the animals showed symptoms of hyperlipemia and they were treated
with 250 μg/kg body weight CrCI3·6H2O and 100 mg/kg body weight niacin, by gavage, for 45 d. On d 60, the blood and the skin and lungs samples were taken from
animals.
In the hyperlipemic groups, a reduction of the lung glutathione level and an increase in serum, lung, and skin lipid peroxidation
levels and in serum sialic and uric acid were observed. In rats treated with a combination of niacin and Cr(III), the skin
and serum lipid peroxidation and the sialic and uric acid levels decreased while showing an increase of lung glutathione activity.
These results suggest that niacin and Cr(III), when administered in combination, have a protective effect against skin and
lung tissues damage as a result of hyperlipidemia. |
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Keywords: | Hyperlipemia skin lungs glutathione lipid peroxidation niacin chromium sialic acid uric acid |
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