Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression |
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| Authors: | E. A. Engleman J. M. Murphy F. C. Zhou J. N. Hingtgen |
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| Affiliation: | (1) Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 46202-4887 Indianapolis, Indiana;(2) Department of Anatomy, Program in Medical Neurobiology, Institute of Psychiatric Research, Indiana University School of Medicine, 46202-4887 Indianapolis, Indiana;(3) Department of Psychology, Purdue School of Science, 46202-4887 Indianapolis, Indiana;(4) c/o Dr. J. N. Hingtgen, Institute of Psychiatric Research, Indiana University Medical Center, 791 Union Drive, 46202-4887 Indianapolis, Indiana |
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| Abstract: | Studies from this laboratory have demonstrated that administration of the selective 5-HT2/1C antagonist LY53857 can block 5-HTP-induced response suppression. To further investigate the serotonergic mechanisms involved in this effect, we decided to test the capacity of LY53857 to block response suppression induced with two selective 5-HT agonists. After a 15 minute baseline period, rats trained to press a lever for milk reinforcement on a VI 1 schedule were given IP injections of 1.0 mg/kg DOI, or 1.0 mg/kg 8-OH-DPAT to induce response suppression. Subsequently, rats were injected with 1.0 mg/kg LY53857 1 hour prior to DOI- or 8-OH-DPAT-induced response suppression. Preinjections with LY53857 resulted in a 100% blockade of DOI-induced response suppression whereas the same dose did not block response suppression induced with 8-OH-DPAT. These results indicate that the 5-HTP-induced response suppression shows some pharmacological similarity to DOI-induced response suppression and may be mediated through 5-HT2 and/or 5-HT1C receptors.Special issue dedicated to Dr. Morris H. Aprison |
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| Keywords: | Behavior serotonin DOI 8-OH-DPAT 5-HTP depression |
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