Homologous recombination: ends as the means |
| |
Authors: | Ray Animesh Langer Marybeth |
| |
Affiliation: | Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA. animesh_ray@kgi.edu |
| |
Abstract: | Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants. However, there is a second somatic pathway of chromosome repair, which is driven by DNA-sequence homology. Observations from yeast, fly and plants of homologous-recombination mechanisms point towards new strategies of gene targeting in plants. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|