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Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin |
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| Authors: | Dries B.A de Bont Gerard D.H Dijkstra Jack A.J den Hartog Rob M.J Liskamp |
| Affiliation: | a Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands b Solvay Pharmaceuticals Research Laboratories, P.O. Box 900, 1308 DA, Weesp, The Netherlands |
| Abstract: | Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported. |
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