Yeast cytochrome c is a sequence-specific DNA-binding protein |
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| Authors: | Bhatnagar Anshu Raghavendra Pralhada Rao Kranthi Balla V Rangarajan Pundi N |
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| Affiliation: | Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India. |
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| Abstract: | A protein binding to the alcohol oxidase 2 upstream activation sequence (AOX2UAS) of the methylotropic yeast, Pichia pastoris, has been purified and identified as cytochrome c (cyt c). Cyt c purified from P. pastoris or Saccharomyces cerevisiae binds to AOX2UAS. Specific point mutations in AOX2UAS abolish cyt c binding. We conclude that yeast cyt c is a sequence-specific DNA-binding protein and may have a regulatory role in the nucleus. |
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