The effect of hydroxyurea and mitomycin C on sperm motility in mice |
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| Authors: | Gyula Ficsor Leonard C Ginsberg |
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| Institution: | Department of Biomedical Sciences, Western Michigan University, Kalamazoo, MI 49008, U.S.A. |
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| Abstract: | The mutagen, mitomycin C, and the teratogen, hydroxyurea, were found to decrease sperm motility in mice in a dose-dependent manner. Positive results with these compounds suggest that sperm motility may have been decreased through either mutations or developmental disturbances. Sperm motility can be determined quickly and may be done in conjunction with a sperm-morphology assay. |
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| Keywords: | HU hydroxyurea MC mitomycin C |
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