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Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation |
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| Authors: | Micheli Fabrizio Pasquarello Alessandra Tedesco Giovanna Hamprecht Dieter Bonanomi Giorgio Checchia Anna Jaxa-Chamiec Albert Damiani Federica Davalli Silvia Donati Daniele Gallotti Chiara Petrone Marcella Rinaldi Marilisa Riley Graham Terreni Silvia Wood Martyn |
| Institution: | GlaxoSmithKline Psychiatry Centre of Excellence for Drug Discovery, Via Fleming, 4, 37135 Verona, Italy. fm20244@gsk.com |
| Abstract: | Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C molecules are reported. |
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