Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors |
| |
Authors: | Ringom Rune Axen Eva Uppenberg Jonas Lundbäck Thomas Rondahl Lena Barf Tjeerd |
| |
Affiliation: | Department of Medicinal Chemistry, Biovitrum AB, SE-751 37 Uppsala, Sweden. |
| |
Abstract: | The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|