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Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance
Authors:Agatha A. van der Klaauw  Sophie Croizier  Edson Mendes de Oliveira  Lukas K.J. Stadler  Soyoung Park  Youxin Kong  Matthew C. Banton  Panna Tandon  Audrey E. Hendricks  Julia M. Keogh  Susanna E. Riley  Sofia Papadia  Elana Henning  Rebecca Bounds  Elena G. Bochukova  Vanisha Mistry  Stephen O’Rahilly  Richard B. Simerly  I. Sadaf Farooqi
Affiliation:1. University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK;2. The Saban Research Institute, Developmental Neuroscience Program, Center for Endocrinology, Diabetes and Metabolism, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA;3. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland;4. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK;5. Pathogenesis of Vascular Infections Unit, INSERM, Institut Pasteur, Paris, France;6. School of Biological and Marine Sciences, University of Plymouth, Plymouth, UK;7. Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, UK;8. Wellcome Sanger Institute, Cambridge, UK;9. Department of Mathematical and Statistical Sciences, University of Colorado-Denver, Denver, CO 80204, USA;10. The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;11. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, TN 37232-0615, USA;12. INSERM U1172, Jean-Pierre Aubert Research Center, Lille, France
Abstract:
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  • Keywords:Semaphorin 3s  Neuropilins  Plexins  hypothalamus  Pomc  AgRP  obesity
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