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A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling
Authors:Yimu Zhao  Naimeh Rafatian  Nicole T. Feric  Brian J. Cox  Roozbeh Aschar-Sobbi  Erika Yan Wang  Praful Aggarwal  Boyang Zhang  Genevieve Conant  Kacey Ronaldson-Bouchard  Aric Pahnke  Stephanie Protze  Jee Hoon Lee  Locke Davenport Huyer  Danica Jekic  Anastasia Wickeler  Hani E. Naguib  Gordon M. Keller  Milica Radisic
Affiliation:1. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada;2. Division of Cardiology and Peter Munk Cardiac Center, University of Health Network; Toronto, ON M5G 2N2, Canada;3. TARA Biosystems, Inc., New York, NY 10016, USA;4. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada;5. Department of Physiology, Faculty of Medicine; University of Toronto; Toronto; Ontario, M5S 1A8, Canada;6. Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada;7. Section of Genomic Pediatrics, Department of Pediatrics and Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA;8. Department of Biomedical Engineering and Department of Medicine, Columbia University, New York, NY 10032, USA;9. Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1A8, Canada;10. McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada;11. BlueRock Therapeutics, MaRS Discovery District, Toronto, ON M5G 1L7, Canada;12. Department of Anatomy and Cell Biology, Faculty of Science, McGill University, Montreal, QC H3A 2K6, Canada;13. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada;14. Department of Biology; York University, Toronto, ON M3J 1P3, Canada;15. Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada
Abstract:
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  • Keywords:Cardiomyocyte  tissue engineering  drug testing  electrophysiology  contractility  atrial  ventricular  heart  calcium transient  action potential  polygenic cardiac disease
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