|
|||||
|
|
Nortriterpenoids and lignans from Schisandra sphenanthera |
|
| Authors: | Xiao Wei-Lie Huang Sheng-Xiong Wang Rui-Rui Zhong Jia-Liang Gao Xue-Mei He Fei Pu Jian-Xin Lu Yang Zheng Yong-Tang Zheng Qi-Tai Sun Han-Dong |
| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China b Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China c Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China |
| Abstract: | Nortriterpenoids, sphenadilactone C (1) and sphenasin A (2), together with four known lignans (3-6), were isolated from the leaves and stems of Schisandra sphenanthera. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data and compound 2 was further confirmed by single-crystal X-ray diffraction. Compound 1 features a partial enol moiety and an acetamide group in its structure. In addition, compounds 1, 3-6 showed weak anti-HIV-1 activity with EC50 values in the range of 15.5-29.5 μg/mL. |
| Keywords: | Schisandra sphenanthera Schisandraceae Nortriterpenoid Lignans Anti-HIV-1 activity |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |