|
|||||
|
|
Non-cannabinoid constituents from a high potency Cannabis sativa variety |
|
| Authors: | Radwan Mohamed M Elsohly Mahmoud A Slade Desmond Ahmed Safwat A Wilson Lisa El-Alfy Abir T Khan Ikhlas A Ross Samir A |
| Institution: | a National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA b Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA c Department of Pharmacology, School of Pharmacy, The University of Mississippi, University, MS 38677, USA d Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA |
| Abstract: | Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and β-sitosteryl-3-O-β-d-glucopyranoside-2′-O-palmitate (6). In addition, five known compounds, α-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and β-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics. |
| Keywords: | Cannabis sativa L Cannabaceae High potency Non-cannabinoid Antimicrobial Antileishmanial Antimalarial Anti-oxidant |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |