Bis-sesquiterpenes and diterpenes from Chloranthus henryi |
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| Authors: | Li Chuang-Jun Zhang Dong-Ming Luo Yong-Ming Yu Shi-Shan Li Yan Lu Yang |
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| Institution: | a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
b Faculty of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China |
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| Abstract: | Bis-sesquiterpenes, henriols A (1), B (2), C (3), and D (4), and three diterpenes, henrilabdanes A (5), B (6), and C (7), together with two known bis-sesquiterpenes and three known labdane diterpenes, were isolated from the ethanol extract of the roots of Chloranthushenryi. Their structures and absolute configurations were elucidated by NMR spectroscopic, X-ray crystallographic and CD analyses. Compounds 1, 5, 6 and 7 showed moderate hepatoprotective activities with IC50 values of 0.19, 0.66, 0.09 and 0.18 μM, respectively. They were not studied further due to the weak effects noted. Compounds 3 and 8 exhibited cytotoxic activities against three types of cancer cell lines including the hepatoma (BEL-7402), human gastric carcinoma (BGC-823), and colon cancer (HCT-8). |
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| Keywords: | Chloranthushenryi Chloranthaceae Bis-sesquiterpenes Diterpenes Henriols Henrilabdanes Hepatoprotective cytotoxicity |
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