Cycloartane glycosides from Astragalus campylosema Boiss. ssp. campylosema |
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Authors: | Caliş Ihsan Dönmez Ali A Perrone Angela Pizza Cosimo Piacente Sonia |
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Affiliation: | a Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey b Department of Biology, Faculty of Science, Hacettepe University, TR-06532 Ankara, Turkey c Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, I-84084 Fisciano, Italy d Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Near East University, Nicosia, Turkish Republic of Northern Cyprus |
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Abstract: | Four cycloartane glycosides, 3-O-[α-l-arabinopyranosyl-(1 → 2)-β-d-xylopyranosyl]-3β,6α,16β,23α,25-pentahydroxy-20(R),24(S)-epoxycycloartane (1), 3-O-[α-l-arabinopyranosyl-(1 → 2)-β-d-xylopyranosyl]-16-O-hydroxyacetoxy-23-O-acetoxy-3β,6α,25-trihydroxy-20(R),24(S)-epoxycycloartane (2), 3-O-[α-l-arabinopyranosyl-(1 → 2)-β-d-xylopyranosyl]-3β,6α,23α,25-tetrahydroxy-20(R),24(R)-16β,24;20,24-diepoxycycloartane (3), 3-O-[α-l-arabinopyranosyl-(1 → 2)-β-d-xylopyranosyl]-25-O-β-d-glucopyranosyl-3β,6α,16β,25-tetrahydroxy-20(R),24(S)-epoxycycloartane (4), along with three known cycloartane glycosides were isolated from the MeOH extract of the roots of Astragalus campylosema ssp. campylosema. Their structures were established by the extensive use of 1D- and 2D-NMR experiments along with ESIMS and HRMS analysis. The occurrence of the hydroxyl function at position 23 (1-2) and of the ketalic function at C-24 (3) are very unusual findings in the cycloartane class. |
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Keywords: | Astragalus campylosema ssp. campylosema Leguminosae 20,24-Epoxycycloartane glycosides 16β,24 20,24-Diepoxycycloartane |
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