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Antibacterial activity of halogenated sesquiterpenes from Malaysian Laurencia spp |
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| Authors: | Vairappan Charles Santhanaraju Suzuki Minoru Ishii Takahiro Okino Tatsufumi Abe Tsuyoshi Masuda Michio |
| Institution: | a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Locked Bag 2073, 88999 Kota Kinabalu, Sabah, Malaysia b Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan c The Hokkaido University Museum, Sapporo 060-0810, Japan d Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan |
| Abstract: | During our studies on Malaysian Laurencia species, brominated metabolites, tiomanene, acetylmajapolene B, and acetylmajapolene A were isolated from an unrecorded species collected at Pulau Tioman, Pahang along with known majapolene B and majapolene A. Acetylmajapolene A was a mixture of diastereomers as in the case of majapolene A. Tiomanene may be a plausible precursor for acetylmajapolenes B and A. In addition, three known halogenated sesquiterpenes and two known halogenated C15 acetogenins were found from other two unrecorded species collected at Pulau Karah, Terengganu and Pulau Nyireh, Terengganu, respectively. Some of these halogenated metabolites showed moderate antibacterial activity against some marine bacteria. |
| Keywords: | Laurencia sp Rhodomelaceae Bioactive metabolites Halogenated sesquiterpenes Halogenated C15 acetogenins Antibacterial activity |
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