Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity |
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| Authors: | Wu Qian Yang Qingrui Lourenco Elaine Sun Hongsheng Zhang Yuanchao |
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| Institution: | (1) Department of Rheumatology, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People’s Republic of China;(2) Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA |
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| Abstract: | Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. Previous studies have suggested
that interferon-lambda 1 (IFN-λ1), a type III interferon, plays an immunomodulatory role. In this study we investigated its
role in SLE, including its correlation with disease activity, organ disorder and production of chemokines. |
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