Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified by aldehyde function |
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Authors: | N V Sumbatyan I V Kuznetsova V V Karpenko N V Fedorova V A Chertkov G A Korshunova A A Bogdanov |
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Institution: | 1.Faculty of Chemistry,Moscow State University,Moscow,Russia;2.Belozersky Institute of Physicochemical Biology,Moscow,Russia |
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Abstract: | Fourteen new functionally active amino acid and peptide derivatives of the antibiotics tylosin, desmycosin, and 5-O-mycaminosyltylonolide were synthesized in order to study the interaction of the growing polypeptide chain with the ribosomal
tunnel. The conjugation of various amino acids and peptides with a macrolide aldehyde group was carried out by two methods:
direct reductive amination with the isolation of the intermediate Schiff bases or through binding via oxime using the preliminarily
obtained derivatives of 2-aminooxy-acetic acid. |
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