Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones |
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| Authors: | G. Turchi H.R. Glatt A. Seidel A. Puliti I. Sbrana |
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| Affiliation: | (1) European Centre for the Validation of Alternative Methods (ECVAM), J.R.C. Environmental Institute, Ispra (Va), Italy;(2) German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany;(3) Institute of Toxicology, University of Mainz, Germany;(4) Dipartimento di Scienze dell!["lsquo"]("/content/j33457280280x500/xlarge8216.gif") Ambiente e del Territorio dell!["rsquo"]("/content/j33457280280x500/xlarge8217.gif") Universita', di Pisa, Italy |
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| Abstract: | Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses. |
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| Keywords: | cultured liver cells chromosomal aberrations structure-activity relationship |
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