Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis |
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| Authors: | Melina Andrade Mattar Bruno Gualano Luiz Augusto Perandini Samuel Katsuyuki Shinjo Fernanda Rodrigues Lima Ana Lúcia Sá-Pinto Hamilton Roschel |
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| Affiliation: | .Division of Rheumatology, School of Medicine, University of São Paulo, São Paulo, Brazil ;.School of Physical Education and Sports, University of São Paulo, São Paulo, Brazil ;.Faculdade de Medicina Universidade de São Paulo - Divisão de Reumatologia, Av Dr Arnaldo, 455 - 3° andar - sala 3131 - Cerqueira César, São Paulo, Brazil |
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| Abstract: | IntroductionOur aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).MethodsIn total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.ResultsThe BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (−4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.ConclusionsWe demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.Trial registrationClinicaltrials.gov {"type":"clinical-trial","attrs":{"text":"NCT01501019","term_id":"NCT01501019"}}NCT01501019. Registered November 29, 2011. |
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