Importance of a semen analysis report for determining the relationship between SCSA sperm DNA fragmentation index and assisted reproductive technology pregnancy rate |
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| Institution: | 1. The Fertility Center from A to Z, Affiliated with Assuta Medical Center, Tel Aviv, Israel;2. The Fertility Clinic, Skive Regional Hospital, Denmark;3. Faculty of Health, Aarhus University, Denmark;4. The Sackler Faculty of Medicine, Tel Aviv University, P.O.B 39040, Tel Aviv, Israel;1. Key Laboratory of Family Planning and Reproductive Genetics, National Health and Family Planning Commission, Shijiazhuang, 050071, China;2. College of Life Science, Hebei Normal University, Shijiazhuang, 050024, China;1. Institute of Biology, University of Brasília, Brasília, Brazil;2. Embrapa Genetic Resources and Biotechnology, Brasília, Brazil;3. Veterinary Medicine Department, University of Espírito Santo, Alegre, Brazil;1. The New York State/American Program, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;2. Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;3. Israel Academic College in Ramat Gan, Israel;1. Universidad de Alicante, Departamento de Biotecnología, Alicante, Spain;2. FISABIO - Hospital Universitario de San Juan de Alicante, Servicio de Ginecología y Obstetricia, San Juan de Alicante, Spain;3. Hospital Universitario San Juan de Alicante, Servicio de Ginecología y Obstetricia, San Juan de Alicante, Spain;4. Universidad Miguel Hernández de Elche, Medicina clínica, San Juan de Alicante, Spain;5. Universidad Miguel Hernández de Elche, División de Ginecología, San Juan de Alicante, Spain;6. Cátedra Human Fertility, Universidad de Alicante, Alicante, Spain |
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| Abstract: | In the past, semen parameters have been the primary diagnostic criteria used to establish male infertility. However, with the exception of sperm motility, which is known to be linked to rates of in vitro fertilization success, these parameters are generally unreliable at accurately predicting the potential fertility of a couple. More recent research has suggested that sperm DNA fragmentation index (DFI) may be a more robust and reliable means of predicting assisted reproductive outcomes.The present study aimed to assess the relationship between sperm motility, sperm DFI, and rates of clinical pregnancy by analyzing data from 3000 couples dealing with infertility. Using the most recent semen analysis reports available from male partners in these couples, we assessed these parameters and found that the lower the sperm DFI value, the higher the rate of clinical pregnancy. When we assessed the correlation between sperm DFI, sperm motility, and clinical pregnancy, we observed a strong negative correlation between DFI and motility, but observed no significant relationship between sperm motility and pregnancy rates. These results thus indicate that the measurement of DFI via a sperm chromatin structure assay (SCSA) may be a valuable tool for analyzing semen in order to better predict and improve pregnancy rates in infertile couples. |
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| Keywords: | Pregnancy rates SCSA Sperm motility DFI |
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