Interrelationships between metabolic hormones,leptin and ghrelin,and oil-related contaminants in control of oxytocin and prostaglandin F release by feline ovaries |
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| Affiliation: | 1. Department of Zoology and Anthropology, Constantine the Philosopher University, Nitra, Slovakia;2. Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland;3. Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia;1. Department of Histology and Embryology, Faculty of Veterinary Medicine, Erciyes University, 38090, Kayseri, Turkey;2. Republic of Turkey Minister of Agriculture and Forestry, 13700, Bitlis, Turkey;1. Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;2. Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, Washington, DC, USA;3. Department of Anatomy, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;1. Federal University of Parana, Department of Veterinary Medicine and Animal Science, Palotina, Paraná, Brazil;2. Brazilian Institute for Conservation Medicine - TRÍADE, Curitiba, Brazil;3. Smithsonian Conservation Biology Institute, Front Royal, Virginia, USA;4. Chester Zoo, Reproduction & Welfare Research Unit, Upton-by-Chester, UK;5. Itaipu Binacional, Refugio Biologico Bela Vista, Foz do Iguaçu, Paraná, Brazil;6. Laboratorio de Dosagens Hormonais, Department of Animal Reproduction, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil;1. Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, Front Royal, VA, 22630, USA;2. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan |
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| Abstract: | We examined the effects of metabolic hormones leptin and ghrelin, and the oil-related environmental contaminants toluene and xylene on the release of ovarian hormones by gravid and non-gravid cats, as well as the functional interrelationships between metabolic hormones and contaminants. Ovarian fragments of non-gravid cats were cultured with and without leptin and toluene. Next, ovarian fragments of either non-gravid or gravid animals were cultured with and without ghrelin and xylene. Oxytocin (OT) and prostaglandin F (PGF) release was measured using ELISA.We confirm ovarian OT and PGF production by feline ovary, demonstrate the involvement of leptin and ghrelin in controlling OT and PGF release, show the direct influence of toluene and xylene on feline ovarian secretory activity, indicate the ability of leptin and ghrelin to mimic and promote the main contaminant effects, demonstrate that oil-related contaminants can prevent and even invert the effects of leptin and ghrelin on the ovary, and suggest the gravidity-associated changes in ability of ghrelin to promote xylene action on PGF (but not to OT), but not in basic ovarian OT and PGF release and their response to ghrelin or xylene. |
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| Keywords: | Toluene Xylene Ovary Oxytocin Prostaglandin Gravidity |
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