House Dust Mite Induced Lung Inflammation Does Not Alter Circulating Vitamin D Levels |
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| Authors: | Ling Chen Kara L Perks Stephen M Stick Anthony Kicic Alexander N Larcombe Graeme Zosky |
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| Institution: | 1. School of Medicine, Faculty of Health, University of Tasmania, Hobart, Tasmania, Australia.; 2. Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.; 3. Telethon Kids Institute, University of Western Australia, Subiaco, WA, Australia.; University of Lisbon, Portugal, |
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| Abstract: | Low circulating levels of 25-hydroxyvitamin D 25(OH)D] are associated with chronic lung diseases such as asthma. However, it is unclear whether vitamin D is involved in disease pathogenesis or is modified by the inflammation associated with the disease process. We hypothesized that allergic inflammation decreases the level of circulating 25(OH)D and tested this using a mice model of house dust mite (HDM) induced allergic airway inflammation. Cellular influx was measured in bronchoalvelar lavage (BAL) fluid, and allergic sensitization and 25(OH)D levels were measured in serum. Exposure to HDM caused a robust inflammatory response in the lung that was enhanced by prior influenza infection. These responses were not associated with any change in circulating levels of 25(OH)D. These data suggest that alterations in circulating 25(OH)D levels induced by Th-2 driven inflammation are unlikely to explain the cross-sectional epidemiological association between vitamin D deficiency and asthma. |
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